New Cernotina Ross 1938 (Trichoptera: Polycentropodidae) from Serra do Divisor, Acre, Brazil.

Two new species of the caddisfly genus Cernotina (Polycentropodidae) are described from the Parque Nacional da Serra do Divisor (PNSD), Acre, Brazil, Cernotina chicomendes sp. nov. and Cernotina divisor sp.

Short physical performance battery in aerobic capacity and physical activity evaluation of individuals with peripheral artery disease: An exploratory study.

Background: Peripheral artery disease (PAD) negatively affects functional ability. Persons with PAD experience gait limitation, and changes in mobility, muscle strength, and balance. Assessing individuals with PAD with tests of lower limb performance during activities other than walking may provide information about aerobic capacity.

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Cellular target engagement technologies enable quantification of intracellular drug binding; however, simultaneous assessment of drug-associated phenotypes has proven challenging. Here, we present cellular target engagement by accumulation of mutant as a platform that can concomitantly evaluate drug-target interactions and phenotypic responses using conditionally stabilized drug biosensors. We observe that drug-responsive proteotypes are prevalent among reported mutants of known drug targets.

Parrondo's effects with aperiodic protocols.

In this work, we study the effectiveness of employing archetypal aperiodic sequencing-namely, Fibonacci, Thue-Morse, and Rudin-Shapiro-on the Parrondian effect. From a capital gain perspective, our results show that these series do yield a Parrondo's paradox with the Thue-Morse based strategy outperforming not only the other two aperiodic strategies but benchmark Parrondian games with random and periodical (AABBAABB…) switching as well. The least performing of the three aperiodic strategies is the Rudin-Shapiro.