A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice.

Current antibody-based immunotherapy depends on tumor antigen shedding for proper T cell priming. Here we select a novel human CD40 agonistic drug candidate and generate a bispecific antibody, herein named BiA9*2_HF, that allows for rapid antibody-peptide conjugate formation. The format is designed to facilitate peptide antigen delivery to CD40 expressing cells combined with simultaneous CD40 agonistic activity.

Deep-learning-based Attenuation Correction for Ga-DOTATATE Whole-body PET Imaging: A Dual-center Clinical Study.

Objectives: Attenuation correction is a critical phenomenon in quantitative positron emission tomography (PET) imaging with its own special challenges. However, computed tomography (CT) modality which is used for attenuation correction and anatomical localization increases patient radiation dose. This study was aimed to develop a deep learning model for attenuation correction of whole-body Ga-DOTATATE PET images.

Fusing together an outline design for sustained fuelling and tritium self-sufficiency.

Ensuring tritium fuel self-sufficiency while maintaining continuous and high-specification fuel flow to the tokamak via a low tritium inventory and controllable fuel cycle is a significant challenge to the STEP plant design. Effective and high-quality fuelling and exhaust design is required to sustain and control a stable plasma, whereas fuel sufficiency is required to prevent depletion of available tritium supply. Concerns regarding the lack of tritium availability preventing continuous tritium import are countered by breeding, where highly energetic neutrons from the core fusion reactions interact with lithium atoms suspended in the surrounding breeder blanket to produce tritium.