Publications by authors named "M C Pfefferkorn"
Background & Aims: HBsAg proteins are useful to identify HBV inactive carriers (ICs), but data on chronic hepatitis D (CHD) are scarce. This study aimed to describe HBsAg composition in CHD, its changes during the evolution, and the potential association with clinical outcomes. In addition, we assess the composition of HBsAg across different HBV genotypes and validate previous results on HBsAg proteins in an independent HBV cohort.
View Article and Find Full Text PDFBackground And Aims: We aimed to determine whether a targeted gene expression panel could predict clinical outcomes in paediatric ulcerative colitis [UC] and investigated putative pathogenic roles of predictive genes.
Methods: In total, 313 rectal RNA samples from a cohort of newly diagnosed paediatric UC patients (PROTECT) were analysed by a real-time PCR microfluidic array for expression of type 1, 2 and 17 inflammation genes. Associations between expression and clinical outcomes were assessed by logistic regression.
Article Synopsis
- - The study investigates the use and effectiveness of antitumor necrosis factor (TNF) biologics in young children diagnosed with very early onset inflammatory bowel disease (VEOIBD) across 25 North American centers from 2008 to 2013, aiming to track treatment initiation and durability over time.
- - Out of 294 children with VEOIBD, 120 started anti-TNF therapy, with a 90% treatment durability at 1 year, which declined to 55% by 5 years, and loss of response was the main reason for discontinuation.
- - The research found that children with Crohn disease had a significantly higher treatment durability than those with ulcerative colitis or IBD unclassified