Publications by authors named "M C Pejenaute Garde"
Background: The innate immune response is important for the development of the specific adaptive immunity, however it may also be associated with reactogenicity after vaccination. We explore the association between innate responsiveness, reactogenicity, and antibody response after first COVID-19 vaccination.
Methods: We included 146 healthy Dutch individuals aged 12-59 who received their first BNT162b2 (Comirnaty, Pfizer) COVID-19 vaccination.
PET analysis is conventionally performed as a two-stage process of quantification followed by analysis. We recently introduced SiMBA (Simultaneous Multifactor Bayesian Analysis), a hierarchical model that performs quantification and analysis for all brain regions of all individuals at once, and in so doing improves both the accuracy of parameter estimation as well as inferential efficiency. However until now, SiMBA has only been implemented for the two-tissue compartment model.
View Article and Find Full Text PDFBackground: To date, it is still not clear why during the COVID-19 pandemic children generally developed no or milder symptoms compared to adults. As innate immune responses are crucial in the early defense against pathogens, we aimed at profiling these responses from both adults and children with a primary SARS-CoV-2 infection.
Methods: In the first months of the pandemic, PBMCs and serum were collected from peripheral blood of adults and children at different time points after testing SARS-CoV-2 PCR positive (PCR+).
Hematopoietic stem cells (HSCs) react to various stress conditions. However, it is unclear whether and how HSCs respond to severe anemia. Here, we demonstrate that upon induction of acute anemia, HSCs rapidly proliferate and enhance their erythroid differentiation potential.
View Article and Find Full Text PDFArticle Synopsis
- Young children and older adults are particularly vulnerable to invasive pneumococcal disease (IPD) due to lower levels of protective antibodies against Streptococcus pneumoniae.
- Research measured IgG and IgA antibodies in serum and saliva across different age groups, revealing that younger children have significantly lower antibody levels and avidity compared to adults.
- The findings suggest that repeated exposure to pneumococci through factors like daycare attendance boosts antibody levels, with young children’s low antibody profiles contributing to their susceptibility to IPD and older adults experiencing different influencing factors.