Publications by authors named "M C Oliveira-de-Souza"
Bougainvillea glabra Choisy bracts extract in free and liposomal forms reduce hyperplasia induced by let-60gain-of-function in Caenorhabditis elegans.
Chem Biodivers
February 2024
In this study, we evaluated the toxicological and antiproliferative effects of B. glabra Choisy bract extract (BGCE) in its free and loaded into liposomes forms administered to C. elegans mutants with let-60 gain-of-function (gf).
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- The COVID-19 pandemic has led to the emergence of multiple SARS-CoV-2 variants that show increased resistance to vaccines and treatments, prompting the need for better tools to study these variants.
- Researchers developed biotin-labeled molecular probes targeting different parts of the SARS-CoV-2 spike protein to help isolate neutralizing antibodies and monitor vaccine effectiveness.
- The study provides a collection of these probes, which can identify immune responses and aid in the characterization of neutralizing antibodies, with constructs made available for wider research use.
Paracetamol-induced hepatotoxicity (APAP) causes severe damage that may be irreversible. Understanding the evolution of liver injury caused by overdose of the drug is important to assist in the treatment. In the present study, we evaluated the acute intoxication by APAP (500 mg/kg) in periods of 3 and 12 hours in C57BL/6 mice through biochemical, histological, inflammatory parameters, and the redox status.
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- The COVID-19 pandemic has led to the evolution of SARS-CoV-2, resulting in various variants that can resist vaccines and treatments, particularly due to mutations in the virus's spike protein.
- The researchers designed biotin-labeled molecular probes for these spike variants, allowing for easier isolation of neutralizing antibodies and assessment of vaccine effectiveness.
- They validated these probes with yeast displaying virus-binding antibodies and made their findings available through Addgene to help further research on immune responses and antibody characterization against COVID-19 variants.
Understanding mechanisms of protective antibody recognition can inform vaccine and therapeutic strategies against SARS-CoV-2. We report a monoclonal antibody, 910-30, targeting the SARS-CoV-2 receptor-binding site for ACE2 as a member of a public antibody response encoded by IGHV3-53/IGHV3-66 genes. Sequence and structural analyses of 910-30 and related antibodies explore how class recognition features correlate with SARS-CoV-2 neutralization.
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