Publications by authors named "M C Oguike"

Objectives: This study was performed to identify and characterize circulating Plasmodium species in three provinces of Mindanao approaching malaria elimination.

Methods: Rapid diagnostic tests (RDT), microscopic examination, and PCR were used to detect malaria parasites. PCR-positive isolates were genotyped for polymorphisms in loci of interest.

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Background: In Nigeria, indiscriminate use of antimalarial drugs may contribute to the threat of drug resistance, but this has not been evaluated among people living with human immunodeficiency virus (HIV).

Methods: HIV-positive adults attending a university hospital HIV clinic and HIV-negative adult volunteers from the university hospital community with a positive blood film were treated with artemether-lumefantrine. Parasite DNA from before and after treatment was polymerase chain reaction amplified to identify molecular markers of drug susceptibility.

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Background: Human ovale malaria is caused by the two closely related species, Plasmodium ovale curtisi and P. ovale wallikeri. Both species are known to relapse from quiescent hepatic forms months or years after the primary infection occurred.

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Article Synopsis
  • The study focuses on the prevalence of Plasmodium ovale and Plasmodium malariae infections, which are rarely investigated in sub-Saharan Africa, particularly among a cohort of 509 individuals in Uganda where Plasmodium falciparum is more common.
  • Findings show that at baseline, the prevalence rates for P. ovale, P. malariae, and P. falciparum infections were 7.5%, 12.6%, and 57.4%, respectively, with co-infections observed in 14.1% of individuals, mostly involving P. falciparum.
  • The study concludes that common red blood cell polymorphisms, like α-thalassaemia
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Background: The aim of this study was to evaluate the creatinine assay on the ABL800 FLEX© blood gas analyzer for the screening of pre-existing renal impairment before radiographic contrast administration in the emergency department (ED), by comparing it with standard practice using central laboratory blood testing.

Methods: The evaluation comprised two elements. The first, conducted in the central laboratory, focused on the analytical performance of the ABL800 creatinine assay.

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