Publications by authors named "M C Oehler"
Cancer stem cells play an important role in tumor progression and chemotherapy resistance. Leucine-rich G repeat-containing protein-coupled receptor 5 (LGR5) has been identified as a cancer stem cell marker in several cancer types. LGR5 is involved in cancer development and progression via several pathways including WNT/β-catenin signaling pathway.
View Article and Find Full Text PDFIntroduction: Polycystic Ovary Syndrome (PCOS) is a multifactorial condition that can include a myriad of symptom complexes. A study in North America demonstrated that a significant percentage of physicians were unaware of crucial aspects of PCOS. This study aimed to examine the level of knowledge about PCOS among physicians in Germany.
View Article and Find Full Text PDFArticle Synopsis
- * The standard treatment—surgery and chemotherapy—causes significant side effects and reduces patients' quality of life, highlighting the need for new, less toxic therapies.
- * Research on plasma-activated media (PAM) shows it may be more effective than traditional chemotherapy, promoting cancer cell death and oxidative stress in HGSOC, paving the way for future clinical applications.
Background: Observational studies have linked vitamin K and cancer, but the causality of this association remains unknown. This Mendelian randomization (MR) study aims to investigate the association between circulating phylloquinone (vitamin K) levels and four female-specific cancers.
Methods: We used four single-nucleotide polymorphisms (SNPs) to instrument phylloquinone, with the reported F-statistic 16.
Objective: Ovarian cancer is characterized by late-stage diagnoses and poor prognosis. We aimed to identify factors that can inform prevention and early detection of ovarian cancer.
Methods: We used a data-driven machine learning approach to identify predictors of epithelial ovarian cancer from 2920 input features measured 12.