Publications by authors named "M C Nahata"
Introduction: The prevalence of exposure to supratherapeutic doses or contraindicated medications based on renal dosing criteria, also known as potentially inappropriately prescribed medications (PIPM), is currently unknown among patients on peritoneal dialysis (PD). The primary objective of this study was to evaluate the prevalence of PIPM in the first year of PD among Medicare patients in the United States.
Methods: This was a retrospective longitudinal cohort analysis of patients starting PD in 2018 in the United States Renal Data System database.
Article Synopsis
- Aquaporin 2 (AQP2) is essential for water reabsorption and urine concentration, and its localization in kidney cells is influenced by anti-diuretic hormones, making it a target for specific medications.
- This study looked at how Goreisan (GRS), a traditional Japanese herbal medicine, affects urine production and AQP2 levels in mice, particularly under conditions induced by desmopressin.
- Findings revealed that GRS enhances diuretic effects by temporarily raising calcium levels in cells and decreasing the accumulation of phosphorylated AQP2 at the kidney's luminal surface, thus helping to regulate urine volume.
: To investigate the effects of prophylactic use of stimulant laxatives and/or docusate on the clinical outcomes in critically ill patients who required mechanical ventilation (MV). : A single-center, retrospective, cohort study was conducted. Patients who received MV in the first 24 h after intensive care unit (ICU) admission were enrolled and divided into four groups: non-laxative, stimulant laxatives, docusate, and stimulant laxatives-docusate combination.
View Article and Find Full Text PDFNewer Therapies for Refractory Infection in Adults: A Systematic Review.
Antibiotics (Basel)
October 2024
Background: () infection is a global health concern, affecting approximately two-thirds of the world's population. Standard first-line treatment regimens often fail, necessitating alternative rescue therapies.
Objectives: This review aims to evaluate the efficacy and safety of newer treatment regimens in patients who have failed initial eradication therapy.