Publications by authors named "M C Moschella"
Article Synopsis
- Thymidylate synthase (TS) is important for DNA synthesis and repair, and its overexpression contributes to drug resistance in cancer cells, particularly in ovarian and colon cancers.
- This study found that novel TS dimer disrupters (Ddis) were more effective at killing cancer cells when used alongside inhibitors of drug efflux proteins, which prevent the drugs from leaving the cells.
- The research also utilized a protein transfection agent to enhance the uptake of these Ddis, leading to reduced TS protein levels and disruptions in the cell cycle, indicating potential for improved cancer therapies.
Article Synopsis
- - The study aimed to gather real-world data on pulmonary arterial hypertension (PAH) with a left heart disease phenotype (PAH-LHD) by reviewing the records of 286 patients from 2001 to 2021 to evaluate their risk of death and treatment outcomes.
- - Results showed that patients with PAH-LHD were generally older, had higher BMI and more cardiovascular issues, but better right ventricular function compared to those without LHD; however, survival rates were similar between both groups despite PAH-LHD patients receiving less aggressive treatment.
- - The COMPERA 2.0 scoring system was found to be effective in assessing mortality risk for PAH-LHD patients during follow-up, indicating that these patients experience less severe
: wear and corrosion can lead to the gross failure of the Morse taper junction with the consequent fracture of the true neck of the prosthetic stem in hip arthroplasty. : 58-year-old male patient, with a BMI of 38 kg/m. Because of avascular necrosis, in 2007, a metal-on-metal total hip arthroplasty was implanted in him, with a TMZF stem and a Co-Cr head.
View Article and Find Full Text PDFBackground: Risk scores are important tools for the prognostic stratification of pulmonary arterial hypertension (PAH). Their performance and the additional impact of comorbidities across age groups is unknown.
Methods: Patients with PAH enrolled from 2001 to 2021 were divided in ≥65 years old vs <65 years old patients.
Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in anticancer therapy. However, treatment with classical substrate-site-directed TS inhibitors induces over-expression of this protein and development of drug resistance. We thus pursued an alternative strategy that led us to the discovery of TS-dimer destabilizers.
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