Publications by authors named "M C Monroe"
Chronic wounds present a major healthcare challenge around the world, and significant hurdles remain in their effective treatment due to limitations in accessible treatment options. Mesenchymal stem cells (MSCs) with multifunctional differentiation and modulatory properties have been delivered to chronic wounds to enhance closure but have limited engraftment when delivered without a scaffold. In this study, hybrid porous hydrogel foams composed of modified polyvinyl alcohol and gelatin were developed that are suitable for rapid and facile MSC encapsulation, fully degradable, and supportive of wound healing.
View Article and Find Full Text PDFIntroduction: The placenta uses lipids and other nutrients to support its own metabolism hence impacting the type and amount of these substrates available to the growing fetus. Maternal obesity and gestational diabetes (GDM) can disrupt placental lipid metabolism and thus lead to altered fetal growth contributing to adverse pregnancy outcomes and developmentally programing the offspring for disease in later life. Understanding obesity and GDM driven changes in placental lipid metabolism is thus important.
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- * Between July 2023 and January 2024, California reported six RMSF cases linked to exposure in Tecate, Mexico, raising concerns as it was previously not identified as a high-risk area, and three of these cases were fatal.
- * Effective detection of RMSF cases necessitated collaborative efforts among various public health agencies, highlighting the need for increased awareness among healthcare providers to enable quicker diagnoses and treatments on both sides of the U.S.-Mexico border.
Article Synopsis
- - The study investigates the impact of social vulnerability on clinical outcomes for hospitalized influenza patients, analyzing data from over 57,000 cases between the 2014-2015 and 2018-2019 influenza seasons across 13 states.
- - It aims to understand how social vulnerability correlates with severe outcomes like ICU admission, use of advanced respiratory support, and 30-day mortality, while also examining patterns of vaccine and antiviral use based on social vulnerability levels.
- - Findings reveal that patients from areas with high social vulnerability experience worse outcomes, such as higher rates of needing invasive ventilation support compared to those from less vulnerable areas.
Article Synopsis
- Understanding protein function requires exploring how various posttranslational modifications (PTMs) work together, but existing methods often struggle to analyze multiple PTMs from a single sample.
- The single-pot, solid-phase-enhanced sample preparation (SP3) method streamlines the process, making it easier to analyze protein abundance and different PTMs like phosphorylation and acetylation simultaneously.
- This SP3 workflow shows promise in a study of β-cells treated with cytokines, revealing rapid protein abundance changes and complex interactions among regulatory pathways, which could help clarify how PTMs influence cellular responses over time.