Publications by authors named "M C Mazzarella"
Introduction: Knowing how metabolic and bariatric surgery (MBS) is indicated in different countries is essential information for the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO).
Aim: To analyze the indications for MBS recommended by each of the national societies that comprise the IFSO and how MBS is financed in their countries.
Methods: All IFSO societies were asked to fill out a survey asking whether they have, and which are their national guidelines, and if MBS is covered by their public health service.
Article Synopsis
- The study aimed to evaluate the feasibility of using isometric myography in pet dogs with myxomatous mitral valve disease (MMVD) to assess endothelial dysfunction.
- Nine dogs were euthanized for medical reasons, and their arterial tissues were extracted postmortem for analysis.
- The results showed that isometric myography is a viable method for detecting impaired endothelial function in dogs with MMVD, which could enhance future research on the disease's mechanisms.
Chagas disease and visceral leishmaniasis are two neglected tropical diseases responsible for numerous deaths around the world. For both, current treatments are largely inadequate, resulting in a continued need for new drug discovery. As both kinetoplastid parasites are incapable of purine synthesis, they depend on purine salvage pathways that allow them to acquire and process purines from the host to meet their demands.
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- MicroRNAs (miRNAs) play a crucial role in regulating gene expression in cells, with this study focusing on their impact in mouse kidney collecting ducts through the selective ablation of Dicer, an enzyme necessary for miRNA formation.
- Results from the experiment on Dicer mice showed severe polyuria and impaired kidney function related to reduced levels of AQP2 and AQP4, alongside a comprehensive analysis of regulated miRNAs and proteins that hints at significant alterations in genetic regulation mechanisms.
- The findings suggest that specific miRNAs are involved in the epigenetic regulation of AQP2, affecting its expression through interactions with transcription factors, despite direct interactions not being demonstrated in the assays conducted.