Effects of RARα ligand binding domain mutations on breast fibroepithelial tumor function and signaling.

Point mutations in the ligand binding domain of retinoic acid receptor alpha (RARα) are linked to breast fibroepithelial tumor development, but their role in solid tumorigenesis is unclear. In this study, we assessed the functional effects of known RARα mutations on retinoic acid signaling using biochemical and cellular assays. All tested mutants exhibited reduced transcriptional activity compared to wild-type RARα and showed a dominant negative effect, a feature associated with developmental defects and tumor formation.

Forward-backward translation, content validity, face validity, construct validity, criterion validity, test-retest reliability, and internal consistency of a questionnaire on patient acceptance of orthodontic retainer.

This study aimed to assess the validity and reliability of a questionnaire on patient acceptance of orthodontic retainers. The original questionnaire was forward- and backward-translated, followed by four validity tests (content validity, face validity, construct validity, criterion validity) and two reliability tests (test-retest reliability, internal consistency). Content validity was assessed by nine orthodontists who appraised the questionnaire's representativeness, relevance, clarity, and necessity.

Case Report: The unrelenting journey-successful resolution of catecholaminergic polymorphic ventricular tachycardia (CPVT) through right cardiac sympathetic denervation in a teenager after left cardiac sympathetic denervation.

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmia disorder characterized by ventricular arrhythmia triggered by adrenergic stimulation.

Case Presentation: A 9-year-old boy presented with convulsions following physical exertion. Bidirectional ventricular tachycardia (VT) during a treadmill test led to the diagnosis of catecholaminergic polymorphic ventricular tachycardia (CPVT).

The Characterisation of Carbapenem-Resistant and in a Teaching Hospital in Malaysia.

: The emergence and dissemination of carbapenem-resistant organisms, particularly and , pose a significant threat to healthcare systems worldwide. This retrospective study aims to characterise carbapenem-resistant (CRAB) and carbapenem-resistant (CRKP) strains in a teaching hospital and to determine the risk factors associated with patients' in-hospital mortality. : A total of 90 CRAB and 63 CRKP were included in this study.

Continuous glucose monitoring in adults with short bowel syndrome receiving overnight infusions of home parenteral nutrition.

Background/objectives: Consumers of home parenteral nutrition (HPN) are susceptible to dysglycemia. The aim was to characterize 24-h glucose profiles of HPN consumers using continuous glucose monitors (CGM) and to identify factors that influence glucose.

Subjects/methods: Glucose profiles of 20 adults with short bowel syndrome (SBS) without diabetes were assessed using the Freestyle Libre Pro CGM.