Publications by authors named "M C Langford"
Biotin is an essential vitamin that is only synthesised in microorganisms, plants and fungi, so the biosynthetic pathway is of interest for antibacterial and herbicide discovery. Plants contain a single, bifunctional enzyme that catalyses two sequential steps in biotin biosynthesis, dethiobiotin synthetase-diaminopelargonic acid aminotransferase (herein referred to as BioDA). Diaminopelargonic acid aminotransferase (BioA) catalyses the pyridoxal phosphate-dependent transamination of 7-keto-8-aminopelargonic acid to produce 7,8-diaminopelargonic acid, while dethiobiotin synthetase (BioD) catalyses the subsequent step to produce dethiobiotin.
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- Gut bacteria, particularly Bacteroides, rely on breaking down complex sugars to survive in the intestines and possess multiple genetic pathways (PULs) for this process.
- Researchers identified the RNA-binding protein RbpB and a group of noncoding RNAs (FopS) as crucial for regulating these pathways at the translation level.
- Disruption of RbpB in Bacteroides thetaiotaomicron negatively affects its ability to colonize the mouse gut based on diet, highlighting how RNA regulation influences the bacteria's adaptation to nutrient changes.
Kieser, J, Langford, M, Stover, E, Tomkinson, GR, Clark, BC, Cawthon, PM, and McGrath, R. Absolute agreement between subjective hand squeeze and objective handgrip strength in adults. J Strength Cond Res 39(1): 16-23, 2025-Despite handgrip strength (HGS) being considered a convenient muscle strength assessment, HGS lacks routine measurement in sports medicine and healthcare settings because barriers such as time and lack of instrumentation may exist.
View Article and Find Full Text PDFPolypharmacy is commonly encountered by providers caring for patients with medically complex and palliative care needs in many settings. The purpose of this quality improvement project was to measure the impact of an evidence-based educational deprescribing intervention on polypharmacy rate and provider confidence and knowledge in the nursing home. We invited providers working in 52 nursing homes to attend a 1-hour-long educational deprescribing session.
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