Publications by authors named "M C Lamers"
The mycobacterial mutasome-comprising ImuA', ImuB, and DnaE2-has been implicated in DNA damage-induced mutagenesis in Mycobacterium tuberculosis. ImuB, which is predicted to enable mutasome function via its interaction with the β clamp, is a catalytically inactive Y-family DNA polymerase. Like some other members of the Y-family, ImuB features a recently identified amino acid motif with homology to the RecA N terminus (RecA-NT).
View Article and Find Full Text PDFBackground: The clinical advantages of light-emitting diode (LED) therapy in skin healing and its underlying mechanism remain subjects of ongoing debate.
Objective: This study aims to explore the impact of LED therapy on normal skin keratinocytes (HaCaT) and in the repair of full-thickness dorsal wounds in Wistar rats.
Methods: HaCaT cell viability (SRB assay) and migration (scratch assay) were assessed under LED therapy, comparing stress conditions (2.
Detection of Double-Stranded RNA Intermediates During SARS-CoV-2 Infections of Syrian Golden Hamsters with Monoclonal Antibodies and Its Implications for Histopathological Evaluation of In Vivo Studies.
Int J Mol Sci
October 2024
Article Synopsis
- * This study investigated viral replication in the lungs of SARS-CoV-2-infected golden hamsters by using anti-dsRNA antibodies, demonstrating that dsRNA detection is most effective during the early stages of infection.
- * Findings suggest that combining dsRNA and viral antigen detection could enhance understanding of viral replication, although further research is required to evaluate dsRNA's potential as an early infection marker in other viruses.
Energy Metabolic Profile in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma: A Preliminary Landscape of Warburg Effect in Oral Cancer.
Mol Carcinog
January 2025
Article Synopsis
- The study investigates how the metabolic energy profiles of oral squamous cell carcinoma (OSCC) cells differentiate from normal and dysplastic tissues, potentially indicating the aggressiveness of the cancer.
- The researchers used mass spectrometry and immunohistochemistry to analyze energy-related proteins and oxidative stress levels in OSCC samples, revealing increased glycolysis and decreased mitochondrial activity in malignant cells compared to adjacent normal tissues.
- Findings suggest that OSCC cells exhibit distinct energy metabolism changes during epithelial-mesenchymal transition, with specific cell lines showing lower mitochondrial function and reactive species levels, which may relate to their aggressiveness and prognosis.
Article Synopsis
- Juvenile xanthogranuloma (JXG) is a type of skin tumor mostly found in children, but some cases occur in other parts of the body, and their genetic causes are not fully understood.* -
- A study analyzed 16 children and 5 adults with extracutaneous JXG using advanced sequencing, finding that numerous genetic alterations, especially related to kinase fusions, were present in most children.* -
- The findings indicate that while surgery is common for treatment, some cases can regress on their own, and specific genetic alterations could help inform better treatment options in the future.*