Publications by authors named "M C Lai"
Article Synopsis
- Accurate diagnosis of Alzheimer's disease and vascular dementia is vital for timely treatment and better patient outcomes; this study focused on plasma and retinal biomarkers for differentiation among cognitive impairment groups.
- The study involved 509 participants aged 50 and older, categorized into groups based on cognitive function using clinical assessments, neuropsychological tests, and MRI scans.
- The findings revealed that both retinal layer thickness and plasma biomarker levels varied significantly across cognitive impairment levels, with decreases seen in retinal thickness and increases in plasma biomarkers from normal cognition to dementia.
Background: Oocyte maturation defect (OMD) and early embryonic arrest result in female infertility. Previous studies have linked biallelic mutations in the PATL2 gene to OMD, yet the underlying mechanism remains largely unknown.
Results: This study uncovers three novel mutations (c.
Background/aims: The increasing use of biologic therapies for moderate to severe inflammatory bowel disease (IBD) highlights the importance of optimal treatment sequencing, particularly after vedolizumab (VDZ) exposure. Studies comparing the effectiveness of ustekinumab (UST) and antitumor necrosis factor (anti-TNF) agents post-VDZ are limited.
Methods: This retrospective study analyzed VDZ-experienced IBD patients treated with UST or anti-TNF (adalimumab and infliximab) from May 2019 to January 2024.
Editorial: Towards an Intersectional Understanding of Sexual Identity, Mental Health, Neurodivergence and Beyond.
J Am Acad Child Adolesc Psychiatry
December 2024
Aim: From 2015 to 2018, the 'Hospital-Acquired Pressure Injury (HAPI)' project was implemented in one local health district in Australia and utilised an implementation science approach to address rising pressure injury (PI) incidence and prevalence rates. This paper aims to examine whether the project was successful in sustaining low PI incidence and prevalence rates over the five-years following implementation (spanning the 2018/2019 to 2022/2023 financial years and the 2019-2023 calendar years).
Materials And Methods: A retrospective cohort study was conducted involving a comprehensive analysis of HAPI incidence, prevalence, and hospital-acquired complication (HAC) data spanning 5 years (incidence and HAC: 2018/2019 to 2022/2023 financial years; prevalence: January 2019 to December 2023 calendar years) post-implementation of the HAPI project.