Publications by authors named "M C Kung"
-(Diphenylphosphinyl)hydroxylamine (DPPH) is a general reagent for the conversion of (hetero)aryl boronic acids and esters to primary anilines. The transformation proceeds rapidly at rt and exhibits a broad substrate scope and exceptional functional-group tolerance. In terms of rate, the reaction is relatively insensitive to the electronic properties of the substrate, in contrast to similar reactions using electrophilic amination reagents such as hydroxylamine--sulfonic acid.
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- The study investigates how mutations in the LRRK2 gene, linked to Parkinson's disease, affect mitochondrial function and calcium signaling during stress-induced cell damage.
- In experiments, the researchers found that while wild-type cells exhibited a normal calcium surge in response to mitochondrial depolarization, LRRK2 mutant cells did not, indicating a disruption in the cellular response to damage.
- Further analysis showed that this lack of response in mutant cells was associated with impaired activation of key kinases involved in the stress response, leading to swollen mitochondria and overall mitochondrial dysfunction.
Article Synopsis
- Continuous improvement in hazard and risk assessment of petroleum-derived substances has evolved since the 1970s, focusing on assessing both traditional and alternative feedstocks.
- Alternative feeds, which include biologically sourced oils and recycled materials, necessitate safety evaluations due to their increasing use in producing liquid hydrocarbons.
- A proposed tiered framework integrates analytical chemistry and testing methods to assess the safety of these hydrocarbons, aiming for efficient and transparent decision-making while ensuring environmental and human safety.
Combining phytochemicals and nanotechnology to improve the unfavorable innate properties of phytochemicals and develop them into potent nanomedicines to enhance antitumor efficacy has become a novel strategy for cancer chemoprevention. Melanoma is the most aggressive, metastatic, and deadly disease of the primary cutaneous neoplasms. In this study, we fabricated phytoconstituent-derived zingerone nanoparticles (NPs) and validated their effects on cell adhesion and motility in melanoma B16F10 cells.
View Article and Find Full Text PDFBackground: Current approaches for initial coronary artery disease (CAD) assessment rely on pretest probability (PTP) based on risk factors and presentations, with limited performance. Infrared thermography (IRT), a non-contact technology that detects surface temperature, has shown potential in assessing atherosclerosis-related conditions, particularly when measured from body regions such as faces. We aim to assess the feasibility of using facial IRT temperature information with machine learning for the prediction of CAD.
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