Publications by authors named "M C Jullien"
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- VEXAS syndrome, identified in 2020, is caused by mutations in the UBA1 gene and shows a variety of clinical and hematological features, making it challenging to distinguish from other inflammatory conditions. !* -
- This study collected a dataset of 9,514 images of polymorphonuclear cells (PMNs) and used a convolutional neural network (CNN) to automate the detection of specific dysplastic features unique to VEXAS, achieving a high level of accuracy (AUC of 0.85-0.97). !* -
- Results indicate that automated analysis can effectively support hematologists in identifying potential VEXAS cases, suggesting a screening score for UBA1 mutational
Article Synopsis
- Graft-versus-host disease (GvHD) is a serious problem that can happen after getting a stem cell transplant.
- Researchers found that a special kind of cells called DP8α Tregs, which help control the immune system, might help prevent GvHD by linking to helpful gut bacteria.
- The study showed that patients with fewer DP8α Tregs were more likely to develop GvHD, suggesting that boosting these cells could be important for preventing this disease.
For most patients with childhood myelodysplastic syndrome (cMDS), allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the only curative option. In the case of increased blasts (cMDS-IB), the benefit of pretransplant cytoreductive therapy remains controversial. In this multicenter retrospective study, the outcomes of all French children who underwent allo-HSCT for cMDS reported in the SFGM-TC registry between 2000 and 2020 were analyzed ( = 84).
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