Publications by authors named "M C Jolly"
Dysregulated pH is now recognised as a hallmark of cancer. Recent evidence has revealed that the endosomal pH regulator Na/H exchanger NHE9 is upregulated in colorectal cancer to impose a pseudo-starvation state associated with invasion, highlighting an underexplored mechanistic link between adaptive endosomal reprogramming and malignant transformation. In this study, we use a model that quantitatively captures the dynamics of the core regulatory network governing epithelial mesenchymal plasticity.
View Article and Find Full Text PDFObjective: Patient education materials (PEMs) can help promote health literacy (HL) among patients. However, their use depends on how easily patients can read and comprehend the information. Several national organizations recommend that text be written at a 6th to 8th-grade level.
View Article and Find Full Text PDFDesign principles of regulatory networks underlying epithelial mesenchymal plasticity in cancer cells.
Curr Opin Cell Biol
November 2024
Phenotypic plasticity is a hallmark of cancer and drives metastatic disease and drug resistance. The dynamics of epithelial mesenchymal plasticity is driven by complex interactions involving multiple feedback loops in underlying networks operating at multiple regulatory levels such as transcriptional and epigenetic. The past decade has witnessed a surge in systems level analysis of structural and dynamical traits of these networks.
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- In mammals, females have two X chromosomes, but one is silenced to balance dosage between sexes, with recent research showing that the active X chromosome (Xa) is upregulated during mouse embryonic development.
- The study explores whether reactivating the inactive X chromosome (Xi) affects Xa upregulation in various cell types, finding a correlation in some contexts like mouse embryonic epiblasts and stem cells, but not in germ cells.
- Additionally, partial reactivation of Xi in certain cells like mouse extra-embryonic endoderm stem cells and human B cells doesn't lead to loss of Xa upregulation, leading to a new mathematical model for how both X chromosomes are coordinated in transcription.
Article Synopsis
- Planar cell polarity (PCP) is crucial for proper embryonic development and functions, with disturbances leading to issues like neural tube defects and hair follicle misalignment.
- The study explores how PCP is established and maintained, highlighting the roles of both global tissue-level gradients and local protein distribution, which have been previously under-examined.
- A minimal model was created that shows PCP can develop without a gradient, but having one enhances stability and resilience against random fluctuations, while simultaneously explaining observed patterns using just three key parameters.