Endocannabinoids, signaling through the cannabinoid CB1 receptor (CB1R), regulate several forms of neuronal plasticity. CB1Rs in the developing primary visual cortex (V1) play a key role in the maturation of inhibitory circuits. Although CB1Rs were originally thought to reside mainly on presynaptic axon terminals, several studies have highlighted an unexpected role for astrocytic CB1Rs in endocannabinoid mediated plasticity.
View Article and Find Full Text PDFIntroduction: Since the early 2000's, the appeal of certain operating room specialties has decreasedamong medical school graduate students. The recent reform of the second and third cycles of medical studies in France provides an opportunity to set up teaching programs around operating room specialties. We have organised a teaching unit which is part of the final year of medical studies.
View Article and Find Full Text PDFBackground: Accidental hypothermia is a manifest problem during the rescue of entrapped victims and results in different subsequent problems as coagulopathy and wound infection. Different warming methods are available for the preclinicial use. However, their effectiveness has hardly been evaluated.
View Article and Find Full Text PDFObjective: To evaluate the incidence, diagnostic management strategies and clinical outcomes of women with spontaneous haemoperitoneum in pregnancy (SHiP) and reassess the definition of SHiP.
Design: A population-based cohort study using the Netherlands Obstetric Surveillance System (NethOSS).
Setting: Nationwide, the Netherlands.
Background: The prognosis of stroke patients can be improved by adherence to clinical guidelines.
Objective: To analyse the current state of organisation of prehospital stroke treatment in Germany, Austria and Switzerland with a focus on guideline adherence.
Materials And Methods: All medical directors of emergency medical services (MDEMS) in Germany ( = 178), Austria ( = 9) and Switzerland ( = 32) were invited to complete an anonymous online survey (unipark.