Publications by authors named "M C Howell"
Sex and gender as predictors for allograft and patient-relevant outcomes after kidney transplantation.
Cochrane Database Syst Rev
December 2024
Background: Sex, as a biological construct, and gender, defined as the cultural attitudes and behaviours attributed by society, may be associated with allograft loss, death, cancer, and rejection. Other factors, such as recipient age and donor sex, may modify the association between sex/gender and post-transplant outcomes.
Objectives: We sought to evaluate the prognostic effects of recipient sex and, separately, gender as independent predictors of graft loss, death, cancer, and allograft rejection following kidney or simultaneous pancreas-kidney (SPK) transplantation.
Objective: To describe the research methods used for the Diet and Health Study, a pilot-feasibility study to assess the impact of a whole-food plant-based vegan diet on college students' physical and mental health.
Design: This 3-week theory-based pilot-feasibility study will employ a stratified, randomized control design (2 intervention groups and 1 comparison group) with measurement of primary and secondary outcomes at baseline and postintervention and end-of-study focus groups.
Setting: Southeastern public state university.
The death of a child is a tragedy of astronomical proportions. Pediatric trauma patients often have injuries so extensive that there is no hope of recovery. Though the tragedy can never be undone, organ donation can save lives and create a legacy for the donor and their loved ones.
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- Thin films of poly(arylene ethynylene)-conjugated polymers can be created using a specialized method called surface-confined Sonogashira cross-coupling, which offers precise control over their structure and organization.
- These polymers boast high stability and significant electronic interactions between chains, enhancing their electronic and spectroscopic properties.
- The resulting fluorescent films are highly sensitive in chemosensing applications, effectively detecting nitroaromatic explosives in water at extremely low concentrations (sub-ppt level) due to improved exciton mobility.
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- Microglia, the brain's immune cells, are vital for neuron health but may worsen conditions like ALS and FTD, and their exact role in these diseases is still unclear.
- Researchers created specialized cultures of microglia from human stem cells with VCP mutations to study their behavior and effects on nearby nerve cells and supportive cells, using advanced techniques like RNA sequencing and proteomics.
- The studies revealed that VCP mutant microglia show immune system and lysosomal issues, react differently to inflammation compared to healthy microglia, and can influence motor neurons and astrocytes through secreted factors, even though certain genetic factors didn't fully address their dysfunction.