Publications by authors named "M C Holden Ko"
Bakuchiol (), a component of , has been reported to have estrogenic, antimicrobial, and anti-inflammatory activities. Nonetheless, its anticancer mechanisms and effectiveness against hepatocellular carcinoma remain unexplored. This study sought to elucidate the mechanism of apoptosis, autophagy, and cell cycle arrest caused by bakuchiol () and three flavonoids (-) with similar structures to compound in hepatocellular carcinoma.
View Article and Find Full Text PDFObjectives: This study evaluated the impact of masticatory difficulty on the development and progression of malnutrition, frailty, sarcopenia, and disability in community-dwelling adults, using data from the Korean Frailty and Aging Cohort Study.
Methods: Participants were categorised by presence of masticatory difficulty. The Fried frailty phenotype, mini-nutritional assessments, and diagnostic criteria proposed by Asian Working Group on Sarcopenia were adopted to diagnose frailty, malnutrition, and sarcopenia respectively.
Background: In emergency general surgery (EGS), rapid judgement and prompt emergency surgery play a significant role in determining the patient's prognosis. This study aimed to evaluate whether implementing the acute care surgery (ACS) system in Korea has improved the clinical outcomes of patients.
Methods: This retrospective cohort study was conducted at three tertiary hospitals in Korea.
Dendritic challenges in Li metal batteries are commonly resolved using porous three-dimensional (3D) current collectors, which have a significant issue in that Li is deposited from the top (top growth) of the structure rather than from the bottom (bottom growth), failing to effectively suppress dendrite growth and volumetric expansion. We propose the structure incorporating a gradient lithiophilic seed within a 3D framework by pulse electroplating Mg, specifically targeting the near bottom to promote bottom growth and achieve dense Li deposition. This method achieves precise control over the catalytic seed size and distribution.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how testosterone affects song production in adult female canaries, which typically do not sing, by analyzing gene regulatory networks in a brain area responsible for song control (HVC) over a period of time after hormone treatment.
- - Female canaries started to vocalize within four days of receiving testosterone, with both song complexity and the brain region's volume increasing over a two-week period.
- - The researchers found that a significant number of genes (over 9,900) were differentially expressed during this time, indicating a complex and dynamic relationship between testosterone and the neural mechanisms involved in song development.