Renal Physiology Education via Podcast: Channel Your Enthusiasm.

Renal physiology is considered one of the most challenging medical disciplines to understand and to teach. Eight academic nephrologists have come together to produce a podcast devoted to helping learners at any level improve their understanding of this difficult topic. Using Dr Burton D.

Potassium Homeostasis.

Potassium homeostasis is essential for maintaining the normal resting membrane potential of excitable cells. Yet daily dietary potassium typically far exceeds total extracellular potassium, thus the body has elegant strategies to shift potassium into cells promptly after a meal and then the kidneys efficiently excrete potassium. Potassium excretion depends on adequate kidney perfusion and filtration, sodium delivery to the distal nephron and aldosterone action on the distal nephron.

Eight induced pluripotent stem cell lines (iPSCs) derived from two patients with Leukocyte adhesion deficiency Type I (LAD I) with mutations in the ITGB2 gene.

Leukocyte Adhesion Deficiency Type I (LAD I) is a rare inborn error of immunity caused by mutations in the ITGB2 gene coding for β2-integrin CD18 on the surface of leukocytes. Affected patients display severe clinical manifestations with life threatening infections and inflammatory complications due to an impaired ability of leukocytes to transmigrate from the blood vessel to the tissue. Here we describe the generation of eight induced pluripotent stem cell lines from two patients with LAD I and mutations in the ITGB2 gene.