The Built Environment, PTSD Symptoms, and Tobacco Use among Permanent Supportive Housing Residents.

Introduction: 50% of permanent supportive housing (PSH) residents in the U.S. smoke cigarettes, and tobacco-related mortality is their number one cause of death.

Mapping Disciplinary Competencies and Learning Outcomes to the Competency-Based Veterinary Education Framework Using Veterinary Pharmacology as an Example.

The competency-based veterinary education (CBVE) framework describes essential domains of competence and related abilities for veterinary graduates. Translating these outcomes into daily teaching is a challenge, particularly regarding the underpinning basic and clinical science knowledge. In this article, we identified a lack of specific reference to the selection and use of drugs within the CBVE framework; this requires pharmacological knowledge and pharmacology-specific competencies.

Social Media Activities and Affective Well-being in the Daily Life of Emerging Adults.

Previous work suggests that some social media (SM) activities may have detrimental effects on users' affective well-being, whereas other activities can be more adaptive. SM use is typically assessed with global or retrospective measures; it remains unclear how its relation with affect may play out in real-time and in regard to specific SM activities, as opposed to general SM use. The current study investigated the association between specific SM activities (posting, viewing others' posts, liking/commenting, checking replies to one's own posts, direct messaging) and concurrent positive and negative affect in a sample of  = 349 18-year-old emerging adults.

Dorsal root ganglion toxicity after AAV intra-CSF delivery of a RNAi expression construct into non-human primates and mice.

Dorsal root ganglion (DRG) toxicity has been consistently reported as a potential safety concern after delivery of adeno-associated viruses (AAVs) containing gene-replacement vectors but has yet to be reported for RNAi-based vectors. Here, we report DRG toxicity after AAV intra-CSF delivery of an RNAi expression construct-artificial microRNA targeting superoxide dismutase 1 (SOD1)-in non-human primates (NHPs) and provide evidence that this can be recapitulated within mice. Histopathology evaluation showed that NHPs and mice develop DRG toxicity after AAV delivery, including DRG neuron degeneration and necrosis and nerve-fiber degeneration that were associated with increases in cerebrospinal fluid (CSF) and serum phosphorylated neurofilament heavy chain (pNF-H).

Obesity and leptin in breast cancer angiogenesis.

At the time of breast cancer diagnosis, most patients meet the diagnostic criteria to be classified as obese or overweight. This can significantly impact patient outcome: breast cancer patients with obesity (body mass index > 30) have a poorer prognosis compared to patients with a lean BMI. Obesity is associated with hyperleptinemia, and leptin is a well-established driver of metastasis in breast cancer.