Publications by authors named "M C Hagan"
Development of cortical visual prostheses requires optimization of evoked responses to electrical stimulation to reduce charge requirements and improve safety, efficiency, and efficacy. One promising approach is timing stimulation to the local field potential (LFP), where action potentials have been found to occur preferentially at specific phases. To assess the relationship between electrical stimulation and the phase of the LFP, we recorded action potentials from primary (V1) and secondary (V2) visual cortex in marmosets while delivering single-pulse electrical microstimulation at different phases of the local field potential.
View Article and Find Full Text PDFIntroduction: Use of oral anticoagulants (OACs) for stroke reduction in atrial fibrillation (AF) varies by race and geography within the United States. We seek to better understand the relationship between OAC underutilization, race, and US geography.
Methods: Patients with AF were selected from the US Centers for Medicare & Medicaid Services claims database from January 1, 2013, to December 31, 2016.
Warfarin and direct-acting oral anticoagulants (DOACs) are widely prescribed to patients with nonvalvular atrial fibrillation (NVAF) to reduce risk of stroke and systemic embolism (SE). This study aimed to assess the cost-effectiveness of apixaban compared with warfarin, dabigatran and rivaroxaban, for patients with NVAF from a US healthcare payer (Medicare) perspective. A cohort-level Markov model was developed based on a previously published model, for the US setting, factoring in anticipated price decreases due to market entry of generic drugs.
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- High mechanical loading induces temporary disruptions in cell membranes (PMD) that initiate a process called mechanotransduction, which is essential for bone adaptation.
- The study hypothesized that disrupting a protein called β2-spectrin (Sptbn1), which supports cell structure, would increase membrane fragility, leading to altered responses in osteocytes (bone cells) under mechanical stress.
- Results showed that disrupting Sptbn1 led to more PMD formation and slower repair rates in cells, impaired cell survival, and reduced bone thickening in response to mechanical loading, highlighting Sptbn1's crucial role in bone adaptation and cell response to stress.
Cells contain intricate protein nanostructures, but replicating them outside of cells presents challenges. One such example is the vertical fibronectin pillars observed in embryos. Here, we demonstrate the creation of cell-free vertical fibronectin pillar mimics using nonequilibrium self-assembly.
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