Publications by authors named "M C Gutierrez-Galhardo"

Background: Pregnant women constitute a vulnerable population occasionally affected by zoonotic sporotrichosis. Treatment is challenging due to potentially teratogenic oral medications (itraconazole and saturated potassium iodide solution) or lack of clinical experience during pregnancy (terbinafine). Literature is scarce on sporotrichosis and pregnancy, mainly consisting of case reports.

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  • Zoonotic sporotrichosis, primarily transmitted by cats, has become highly prevalent in Rio de Janeiro, with a study focusing on 43 non-zoonotic cases revealing important epidemiological and clinical data.
  • The majority of patients were male and common sources of infection included injuries from plants and soil contact, with a specific fungal species being predominantly responsible for the infections.
  • Antifungal susceptibility tests showed some strains resistant to treatment, highlighting the need for ongoing monitoring of antifungal resistance and further investigation into the environmental factors contributing to sporotrichosis.
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  • Sporotrichosis diagnosis requires various tests like culture and serum antibody detection, but these methods can sometimes lead to incorrect results.
  • This study focused on different patient groups to determine how well specific antibody tests work, using an ELISA method to check for various antibodies in serum samples.
  • Findings indicated that certain patients, especially those with nasal lesions and hypersensitivity, had a higher chance of getting false-negative results in antibody detection, highlighting the diagnostic challenges of sporotrichosis.
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Twenty-five years have passed since the initial observation of endemic zoonotic sporotrichosis in Rio de Janeiro, Brazil. Since then, this disease has spread throughout South America. Accompanying the emergence of this mycosis, some progress has been made, including the expansion of a research network in this field and higher visibility of sporotrichosis within government authorities and funding agencies.

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Sporotrichosis is the most frequent subcutaneous or implantation mycosis in Latin America, and its transmission occurs as a result of traumatic inoculation into the skin by organic matter containing the thermodimorphic fungi of the genus . Although cutaneous forms are more common, another important site is the osteoarticular system, whose hematogenous involvement is commonly associated with disseminated forms, especially in people who have an immunosuppressive condition, such as HIV/AIDS, chronic steroid use, and alcohol abuse. We present two cases of osteoarticular sporotrichosis of the knee caused by and followed up at our institution, with different outcomes.

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