Airborne metals and microorganisms during work with historical books - Exposure and biomonitoring.

Exposure to metals and microorganisms can pose health risks. Historical books often contain pigments with metals, and fungi. The aim of this study is to obtain knowledge about exposure to eight metals and microorganisms in a library in Denmark.

The transcription factor ZNF469 regulates collagen production in liver fibrosis.

Metabolic dysfunction-associated steatotic liver disease (MASLD)-characterized by excess accumulation of fat in the liver-now affects one third of the world's population. As MASLD progresses, extracellular matrix components including collagen accumulate in the liver causing tissue fibrosis, a major determinant of disease severity and mortality. To identify transcriptional regulators of fibrosis, we computationally inferred the activity of transcription factors (TFs) relevant to fibrosis by profiling the matched transcriptomes and epigenomes of 108 human liver biopsies from a deeply characterized cohort of patients spanning the full histopathologic spectrum of MASLD.

Paracetamol Overdoses Among Danish Adolescents: A COVID-19 Perspective.

Aim: This study examines trends in paracetamol overdoses among Danish adolescents during and following the COVID-19 pandemic.

Methods: A retrospective observational study was conducted using data from the national databases, covering all paediatric departments in Denmark from January 2016 to December 2023. Patients between 10 and 19 years of age diagnosed with paracetamol overdose were stratified by sex, age and number of hospital admissions.

Characterization of bioaerosol exposures in wastewater treatment plant workers and serum levels of lung and inflammatory markers.

Wastewater treatment plant (WWTP) workers are exposed to bioaerosols containing bacteria, fungi, and endotoxin, potentially posing health risks to workers. This study quantified personal exposure levels to airborne bacteria and fungi, endotoxin, and dust among 44 workers during two seasons at four WWTPs. Associations between the exposure measurements and serum levels of biomarkers CRP, SAA, and CC16 were also assessed.

Cephalopod-inspired jetting devices for gastrointestinal drug delivery.

Needle-based injections currently enable the administration of a wide range of biomacromolecule therapies across the body, including the gastrointestinal tract, through recent developments in ingestible robotic devices. However, needles generally require training, sharps management and disposal, and pose challenges for autonomous ingestible systems. Here, inspired by the jetting systems of cephalopods, we have developed and evaluated microjet delivery systems that can deliver jets in axial and radial directions into tissue, making them suitable for tubular and globular segments of the gastrointestinal tract.