Publications by authors named "M C Fraile-Alonso"
Background/objectives: Complications of hematopoietic stem cell transplant (HSCT) include acute graft-versus-host disease (aGVHD). Severe cutaneous aGVHD can present with generalized erythroderma, desquamation, and bullae which can mimic toxic epidermal necrolysis (TEN). TEN occurs in response to a culprit medication.
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- Atopic dermatitis (AD) is a chronic skin condition that often begins in childhood and can lead to other health issues, with dupilumab being the first biologic treatment approved for moderate to severe cases in adults and adolescents.
- A study reviewed the off-label use of dupilumab in children, showing that 89.5% of patients accessed the medication after about 9 weeks, with varying dosing guidelines based on age.
- The findings indicated that children generally tolerated dupilumab well, but optimal dosing for those under 12 years is still unclear, and the study faced limitations in data collection due to its retrospective nature.
Striated muscle hamartoma (SMH) is a rare, congenital or acquired, benign tumor that predominantly affects children. Therapeutic management has classically been surgical intervention. We present a pediatric case of a facial plaque-type SMH with spontaneous regression that highlights the importance of clinical observation for a conservative approach.
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