Publications by authors named "M C Fishman"
Extended-release buprenorphine induction in opioid non-tolerant incarcerated individuals.
Drug Alcohol Depend Rep
September 2024
Background: Buprenorphine maintenance treatment remains unavailable in most jails in the US. We provide data on a four-day rapid sublingual buprenorphine (SL-B) induction strategy followed by a weekly dose of extended-release injectable buprenorphine (XR-B) with incarcerated individuals with opioid use disorder (OUD) who were not opioid tolerant.
Methods: Between October 2020 to April 2024, = 65 individuals with an opioid use disorder in jails participating in a larger randomized, controlled trial received SL-B and XR-B prior to release.
To evaluate the association of parenteral epinephrine and terbutaline use on ventilatory support in children admitted to the intensive care unit (ICU) with critical asthma in the United States. Data were obtained from the Pediatric Health Information System data base for children ages 2 to 18 years admitted to the ICU with a diagnosis of asthma exacerbation from January 1, 2016, to December 31, 2023. The primary outcomes included noninvasive ventilation (NIV) and/or invasive mechanical ventilation (IMV) use after receipt of terbutaline and/or epinephrine.
View Article and Find Full Text PDFTransient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of futility-induced passivity in larval zebrafish, reversing the "giving-up" response that normally occurs when swimming fails to cause forward movement. Whole-brain imaging revealed that ketamine hyperactivates the norepinephrine-astroglia circuit responsible for passivity.
View Article and Find Full Text PDFArticle Synopsis
- Traditional pain studies have focused on single pain scores, which don't fully capture the complex effects of chronic pain on a person's daily life, mood, and overall quality of life.
- The study evaluated the Nalu™ Neurostimulation System for treating low-back and leg pain through a 90-day follow-up of patients implanted with this device at 15 pain centers in the US.
- Results showed that 94% of participants achieved meaningful improvements in at least two patient-reported outcomes, indicating the system's effectiveness in managing chronic pain.
Article Synopsis
- This study explores how Adverse Childhood Experiences (ACEs) affect the risk of developing Posttraumatic Stress Disorder (PTSD) in adults undergoing residential treatment for Substance Use Disorder (SUD), suggesting a link between impulsivity and PTSD.
- The research involved 134 adults in treatment, using questionnaires to measure their levels of ACEs, PTSD symptoms, and impulsivity, ultimately finding that two-thirds of participants showed potential PTSD symptoms.
- Among various impulsivity traits examined, lack of premeditation specifically partially mediated the connection between ACEs and PTSD symptoms, highlighting its importance in understanding PTSD development in the context of SUD.