Publications by authors named "M C Fidler"
Article Synopsis
- Scientists found that using two medications together, one that stops cancer and another that helps blood vessels, can help people with a certain type of lung cancer live longer without their cancer getting worse.
- They ran a study (called the RAMOSE trial) comparing one medication plus the blood vessel helper to just the medication alone.
- The results showed that people taking both medications had better outcomes, living longer without cancer progression, even though both groups experienced side effects from the treatments.
Background: The primary objective of this study was to assess the frequency of body composition increases and their relationships to changes in body weight in two cohorts of real world, treatment-naïve, advanced non-small cell lung cancer (NSCLC) patients. One cohort received the current standard of care (CSOC), which consisted of immunotherapy and newer chemotherapy regimens, and the other cohort was treated with the former standard of care (FSOC), consisting only of older platinum-containing regimens.
Methods: CSOC (n = 106) and FSOC (n = 88) cohorts of advanced NSCLC patients were included in this study.
Membranous nephropathy (MN) results from accumulation of antigen-antibody immune complexes along the subepithelial region of the glomerular basement membranes. Over the last years, 13 target antigens have been discovered and include PLA2R, THSD7A, EXT1 and EXT2, NELL1, SEMA3B, NCAM1, CNTN1, HTRA1, FAT1, PCDH7, NTNG1, PCSK6 and NDNF, accounting for 80-90% of MN antigens. MN associated with many of these antigens have distinctive clinicopathologic findings.
View Article and Find Full Text PDF[Posterior reversible encephalopathy syndrome in autoimmune disorders].
Zh Nevrol Psikhiatr Im S S Korsakova
August 2024
Article Synopsis
- Posterior reversible encephalopathy syndrome (PRES) presents with a mix of general and specific neurological symptoms, along with distinct neuroimaging signs showing swelling mainly in the back of the brain.
- Although often linked to sudden high blood pressure, PRES can also occur in patients without hypertension, especially those with autoimmune diseases or exposure to toxic substances.
- The underlying causes of PRES involve problems with blood flow regulation in the brain due to high blood pressure and harmful effects from both natural and external substances.
Introduction: IgG4-related disease (IgG4-RD) is a systemic immune-mediated disease that can involve nearly any organ. IgG4-RD can affect the kidney in different disease patterns, collectively referred to as IgG4-related kidney disease (IgG4-RKD).
Methods: We conducted a tissue-based cohort study with clinicopathological correlation in 125 patients with IgG4-RKD.