Publications by authors named "M C Ferrada"
Article Synopsis
- VEXAS syndrome is a genetic disorder that causes bone marrow failure and systemic inflammation, which can lead to a higher risk of infections for affected patients.
- In a study of 94 patients with VEXAS, 6% developed pneumonia (PJP), 15% experienced reactivation of the alphaherpesvirus, and 10% had non-tuberculous mycobacterial infections.
- The research found that developing PJP or NTM significantly increases the risk of death, while prophylactic treatments for these infections were shown to be highly effective in reducing infection rates.
Article Synopsis
- VEXAS syndrome is a genetic disease primarily affecting older men, characterized by systemic inflammation, bone marrow failure, and skin issues, with an estimated prevalence of 1 in 4269 men over 50.
- A study of 112 patients revealed that 83% experienced skin involvement, making it a common symptom, with various histopathologic findings indicating conditions like leukocytoclastic vasculitis and neutrophilic dermatosis.
- Specific genetic variants were linked to different skin manifestations; treatment with oral prednisone was effective in improving skin symptoms for a majority of patients.
Relapsing polychondritis is a rare inflammatory disease characterized by recurrent inflammation of cartilaginous structures, mainly of the ears, nose and respiratory tract, with a broad spectrum of accompanying systemic features. Despite its rarity, prompt recognition and accurate diagnosis of relapsing polychondritis is crucial for appropriate management and optimal outcomes. Our understanding of relapsing polychondritis has changed markedly in the past couple of years with the identification of three distinct patient clusters that have different clinical manifestations and prognostic outcomes.
View Article and Find Full Text PDFA consistent association has been observed between internet addiction and symptoms of social anxiety. However, there is a lack of empirical research that delves into potential explanations for this relationship and its directionality, making it difficult to translate findings into development of interventions for social anxiety that account for technology-related behaviors. The present study aimed to evaluate the longitudinal dynamics between internet addiction, symptoms of social anxiety, avoidance of social interactions, and using the internet to cope with loneliness.
View Article and Find Full Text PDFArticle Synopsis
- VEXAS syndrome is an autoinflammatory disorder linked to mutations in the UBA1 gene, with thrombosis being a significant clinical feature affecting 49% of patients.
- The majority of thrombosis cases were venous thromboembolism (VTE), often occurring unprovoked, recurrent, and sometimes even in patients on anticoagulants.
- Despite the high incidence of VTE, overall patient survival was good, with an 88% survival rate over nearly 5 years, indicating that thrombosis does not significantly impact long-term survival in these patients.