Anti-IL-6R Ab tocilizumab to treat paraneoplastic inflammatory syndrome of solid cancers.

Background: Paraneoplastic inflammatory syndrome (PIS) with fever and biological inflammation is a rare but severe condition often caused by the systemic production of interleukin 6 (IL-6) by cancer cells. We report on the efficacy of tocilizumab, an anti-IL-6 receptor antibody, in 35 patients with severe PIS.

Patients And Methods: All 35 patients with solid cancers (sarcomas, lung carcinoma, and breast carcinoma) diagnosed with a PIS from 2019 to 2024 treated with tocilizumab were analyzed in this single-center study (health authorities' approval R201-004-478).

Pulmonary involvement in transthyretin cardiac amyloidosis: a case report.

Background: Amyloidosis is a systemic disorder characterized by the deposition of misfolded proteins in various organs. While cardiac transthyretin amyloidosis (ATTR) is well-recognized, pulmonary involvement is rare and often overlooked in clinical practice.

Case Summary: We present a case of severe, and ultimately fatal, cardiac and pulmonary ATTR amyloidosis in a 67-year-old male.

Multiparameter growth-performance monitoring of Holstein dairy heifers fed on moderate- or high-energy feeding plans from birth to puberty.

Today, dairy cattle farmers are seeking to optimize expenditure and productivity throughout the lives of their animals by focusing on efficiency at all levels. One strategy for bringing forward the start of a dairy cow's profitability phase is to advance the onset of puberty and reduce the animal's age at their first calving. Thus, one objective of this study was to feed two groups of Holstein dairy heifers the same diet but in different quantities, with the aim of generating a growth differential of at least 200 g/day between the two groups.

Coronary Sinus Narrowing for Treating Refractory Angina: REDUCER-I Multicenter "Real-World" Observational Study Primary Endpoint Analysis.

Background: Patients with refractory angina are often ineligible for revascularization and have poor quality of life despite optimal medical therapy. The coronary sinus (CS) Reducer (Shockwave Medical Inc) was safe and effective in the treatment of refractory angina in the COSIRA (Coronary Sinus Reducer for Treatment of Refractory Angina) randomized sham-controlled trial.

Objectives: This study sought to perform the primary endpoint analysis of the complete REDUCER-I (An Observational Study of the Neovasc Reducer System) study cohort.

[Spotting the unthinkable. Tips for detecting incest].

Identifying the signs that an infant, child or adolescent is a victim of incest is a complex process. Contradictory psychic mechanisms can interfere with the professional's position: how to think about the unspeakable and the unthinkable in a confused and confusing context? Faced with this sensitive issue, it's important to offer some food for thought on how to tackle it. Children speak to us, with words but above all with their bodies.