Longitudinal Outcomes in Pi*MZ Alpha-1 Antitrypsin Deficient Individuals with Tobacco Smoking History from the SPIROMICS Cohort.

Background: Reliable data about the natural history of lung function decline in alpha-1 antitrypsin (AAT) deficient Pi*MZ heterozygotes is largely missing. We hypothesized that, in adults with a tobacco smoking history, lung function deteriorates faster in Pi*MZ compared to Pi*MM genotype.

Methods: We identified 1856 Pi*MM and 79 Pi*MZ participants with ≥20 pack-years tobacco smoking history from the SPIROMICS cohort by DNA sequencing and followed them over a median of 4.

Older Maternal Age at First Delivery as a Risk Factor for Pelvic Organ Prolapse: What We Know.

Older chronological age and vaginal childbirth are widely accepted risk factors of pelvic organ prolapse (POP). However, considerably less attention has been given to the impact of maternal age at first delivery. Ample research has demonstrated the deleterious effects of age on the musculoskeletal system, including the loss of muscle mass and strength as well as diminished recovery after stress.

Fine structure in the decay of Hg and Au.

The -decay fine structure of Hg and Au was studied by means of decay spectroscopy. Two experiments were performed at the Accelerator Laboratory of the University of Jyväskylä (JYFL), Finland, utilizing the recoil separator RITU and a digital data acquisition system. The heavy-ion induced fusion-evaporation reactions Kr +  Ru and Kr +  Mo were used to produce the Hg and Au nuclei, respectively.

Land-use and socioeconomic time-series reveal legacy of redlining on present-day gentrification within a growing United States city.

Home Owners' Loan Corporation (HOLC) maps illustrated patterns of segregation in United States cites in the 1930s. As the causes and drivers of demographic and land-use segregation vary over years, these maps provide an important spatial lens in determining how patterns of segregation spatially and temporally developed during the past century. Using a high-resolution land-use time series (1937-2018) of Denver, Colorado, USA, in conjunction with 80 years of U.