Naturally occurring asbestos in Southern Italy: Geological and mineralogical investigation of fibrous antigorite from Calabrian serpentinites in view of its hazard assessment.

In the last few decades, non-occupational asbestos-related diseases have been documented in populations living near naturally occurring asbestos (NOA) sites, including regions in Greece, Cyprus, China, New Caledonia, Turkey, and Italy. This highlights the critical need to assess geological and environmental hazards associated with NOA. Fibrous antigorite, among the >400 naturally occurring fibrous minerals, has emerged as a potential health and environmental hazard.

Neoplasia detection via colonic surveillance among young individuals with MSH6 and PMS2-associated Lynch Syndrome.

Purpose: The age to initiate colonoscopy in MSH6/PMS2-associated Lynch Syndrome (LS) remains uncertain. Herein we characterize colonoscopy findings among young individuals with MSH6/PMS2-associated LS.

Methods: Retrospective review of a multi-institutional cohort of individuals with MSH6/PMS2-LS undergoing colonoscopy prior to age 50 was performed.

Post-COVID-19 Small Fiber Neuropathy as a New Emerging Quality of Life-Threatening Disease: A Systematic Review.

Post-acute sequelae of COVID-19 (PASC) syndrome is considered an emergent and diffuse multidisciplinary problem. Compelling evidence suggests that COVID-19 increases symptoms of pre-existent small fiber neuropathy (SFN) and might trigger de novo onset of SFN. In this systematic review, for the first time, we provide a comprehensive overview of the clinical and diagnostic features of PASC-SFN, including the accompanying disorders, disease evolution, and possible treatments, described in the recent literature.

Immune Checkpoint Blockade Response in Mucinous Tubular and Spindle Cell Carcinoma.

Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare kidney tumor which is usually characterized by indolent disease physiology. While several high-grade and sarcomatoid MTSCC tumors have been reported, the clinical experience with contemporary immune checkpoint blockade (ICB) combination therapies extrapolated from treatment paradigms of conventional renal cell carcinoma (RCC) remains limited. Here, we report two patients with metastatic MTSCC treated with first-line ipilimumab plus nivolumab therapy who both achieved great clinical benefit.

Cerebrovascular events with self-expanding versus balloon-expandable valves in patients with or without peripheral arterial disease.

Objectives: The authors compared the risk of cerebrovascular events (CVE) with self-expanding vales (SEV) vs balloon-expandable valves (BEV) in patients with or without peripheral artery disease (PAD), stratified by the access route and the complexity of PAD (Hostile score).

Methods: The PAD-related risk of CVE between SEV vs BEV was investigated using data from the HOSTILE Registry, an observational study including 1707 patients with severe PAD undergoing transcatheter aortic valve replacement (TAVR) via different access routes. The relative risk of CVE with SEV vs BEV in patients without PAD was investigated in a meta-analysis of randomized controlled transfemoral access (TFA)-TAVR trials of patients with normal femoral arteries.