Publications by authors named "M C Castro-Villegas"
Complement component 3 as biomarker of disease activity and cardiometabolic risk factor in rheumatoid arthritis and spondyloarthritis.
Ther Adv Chronic Dis
October 2020
Objective: To analyze the relationship between complement component 3 (C3) and the prevalence of cardiometabolic risk factors and disease activity in the rheumatic diseases having the highest rates of cardiovascular morbidity and mortality: rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA).
Methods: This is a cross-sectional study including 200 RA, 80 PsA, 150 axSpA patients and 100 healthy donors. The prevalence of cardiometabolic risk factors [obesity, insulin resistance, type 2 diabetes mellitus, hyperlipidemia, apolipoprotein B/apolipoprotein A (apoB/apoA) and atherogenic risks and hypertension] was analyzed.
Article Synopsis
- The study aimed to assess how the ASAS Health Index (ASAS-HI) relates to disease activity and overall health impact in patients with spondyloarthritis (SpA).
- A total of 126 patients were evaluated, revealing a strong correlation between ASAS-HI scores and indicators of disease activity and functionality, particularly in individuals with accompanying fibromyalgia (FM).
- Findings emphasized that higher ASAS-HI scores were linked to increased disease activity and worse functionality, suggesting that FM presence should be carefully evaluated in patients with SpA.
Article Synopsis
- - The study aims to improve the classification and treatment of systemic autoimmune diseases by identifying molecular clusters, moving beyond traditional clinical diagnosis methods.
- - Researchers analyzed blood samples from 955 patients and 267 healthy controls, discovering four distinct clusters: three linked to inflammatory responses and one related to low disease activity associated with healthy controls.
- - The findings suggest that these molecular clusters are stable over time and can aid in understanding disease mechanisms and improving treatment strategies, potentially changing how systemic autoimmune diseases are approached in clinical settings.
Assessment of the relationship between estimated cardiovascular risk and structural damage in patients with axial spondyloarthritis.
Ther Adv Musculoskelet Dis
December 2020
Aims: To evaluate the association of estimated cardiovascular (CV) risk and subclinical atherosclerosis with radiographic structural damage in patients with axial spondyloarthritis (axSpA).
Methods: Cross-sectional study including 114 patients axSpA from the SpA registry of Córdoba (CASTRO) and 132 age- and sex-matched healthy controls (HCs). Disease activity and the presence of traditional CV risk factors were recorded.
Comment on: Development and validation of an alternative ankylosing spondylitis disease activity score when patient global assessment is unavailable.
Rheumatology (Oxford)
February 2021