Central blood pressure estimation from radial artery in septic shock.

Pulse Pressure (PP) increases progressively from the central arteries to the peripheral arteries, this well-established hemodynamic phenomenon is called pulse pressure amplification (PPA). Acute critically ill patients may be subject to profound alterations of cardiac and arterial properties. However, blood pressure (BP) is commonly monitored from one peripheral catheter only.

Arterial pulse wave analysis can detect vascular alterations in response to therapy in septic shock.

The severe vascular decoupling induced by septic shock may dissociate the physiological relation between pressure and flow in the periphery and this may have important clinical implications. We hypothesize that arterial pulse wave analysis (PWA) can track these vascular alterations and we tested this hypothesis in a swine experiment of septic shock and resuscitation with different drugs that differently interact with the cardiovascular system. PWA was found to effectively detect the different arterial response to treatment, proving to be highly informative in the monitoring of therapy response in septic shock.

Blood Flow Estimation from Invasive Arterial Blood Pressure: a Black-Box Approach.

The central arterial blood pressure (ABP) waveform is the result of the summation of a forward wave (P ) generated by ventricular contraction and a reflected wave (P) from arterial reflections. Wave separation analysis (WSA) is the gold standard for assessing P and P, and involves the simultaneous registration of ABP and arterial blood flow (ABF). However, the measurement of ABF is typically invasive or not commonly available in clinical settings.

Estimation of pulse wave analysis indices from invasive arterial blood pressure only for a clinical assessment of wave reflection in a 5-day septic animal experiment.

Wave separation analysis (WSA) is the gold standard to analyze the arterial blood pressure (ABP) waveform, decomposing it into a forward and a reflected wave. It requires ABP and arterial blood flow (ABF) measurement, and ABF is often unavailable in clinical settings. Therefore, methods to estimate ABF from ABP have been proposed, but they are not investigated in critical conditions.

Dynamic interplay of cNHEJ and MMEJ pathways of DNA double-strand break repair during embryonic development in zebrafish.

Double strand breaks (DSBs) are the most deleterious DNA lesions as they frequently result in mutations when repaired by canonical non homologous end-joining (cNHEJ) and microhomology-mediated end-joining (MMEJ). Here, we investigated the relative importance of cNHEJ and MMEJ pathways during zebrafish embryonic development. We have analyzed the expression of cNHEJ and MMEJ related genes and found that it was dynamic during development and often become increased in specific tissues.