Publications by authors named "M C Cantone"
Article Synopsis
- The rise of personalized medicine has highlighted the importance of comprehensive genomic profiling (CGP), but challenges in assay standardization and understanding bioinformatics hinder uniform implementation.
- Two in-house CGP assays were compared in a research context, revealing both agreements and significant differences in detecting genetic variants and providing clinical recommendations.
- These discrepancies were attributed to varied bioinformatics methods for variant analysis, emphasizing the need for careful consideration in implementing high-quality CGP to ensure consistent and reliable genomic insights.
Exploring the multifaceted antitumor activity of axitinib in lung carcinoids.
Front Endocrinol (Lausanne)
July 2024
Article Synopsis
- Lung carcinoids (LCs) are rare neuroendocrine tumors in the lungs, representing 20-25% of neuroendocrine tumors and 1-2% of lung cancers, making anti-angiogenic therapies like axitinib (AXI) potential treatment options.
- In a study, three LC cell lines were treated with AXI to assess its long-term effects, focusing on cell cycle changes, apoptosis, and mechanisms like senescence and mitotic catastrophe.
- Results indicated that AXI effectively inhibits tumor growth by causing indirect DNA damage, but its efficacy may decrease if DNA damage is repaired, emphasizing the importance of DNA damage in its therapeutic action.
Dementia and the other neurodegenerative disorders represent a complex pathophysiological process [...
View Article and Find Full Text PDFSince its introduction nearly 30 years ago, Transcranial Magnetic Stimulation (TMS) has increasingly been used to both provide novel insights into the pathophysiology of the neural circuitry that underlies neurological and psychiatric diseases and to manipulate neural activities in a non-invasive manner [...
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