Identifying germline pathogenic variants in breast cancer using tumor sequencing.

Purpose: To investigate the performance of an in-house tumor sequencing panel to identify patients with breast cancer and a germline pathogenic variant (gPV).

Patients And Methods: Retrospective and blinded tumor sequencing analysis in 90 patients with breast cancer and prior germline genetic testing (45 non-carriers and 45 carriers of a gPV) using an in-house panel (VHIO-300). Sensitivity (S), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) of tumor sequencing were calculated.

Impacts of Yacon Syrup () on Human Health: A Systematic Review of Scientific Evidence from the Last Decade.

Background/objectives: Yacon syrup () has gained attention due to its high concentration of fructooligosaccharides (FOSs) and associated health benefits. This systematic review aimed to evaluate the effects of yacon syrup on metabolic parameters and intestinal health in humans over the last decade.

Methods: Following PRISMA guidelines, we conducted a systematic search in databases, including Medline (PubMed), Science Direct, Embase, Scopus, and SciELO, up to October 2024.

Advancing Power Transformer Cooling: The Role of Fluids and Nanofluids-A Comprehensive Review.

The ongoing pursuit of enhanced efficiency and sustainability in power transformer cooling systems has spurred extensive research into the properties and performance of insulating fluids. This review explores the evolution of transformer cooling technologies, focusing on traditional mineral oils and the emerging roles of alternative fluids, such as natural and synthetic esters, and nanofluids. Mineral oils, though widely used, degrade over time, leading to a reduction in breakdown voltage (BDV) from 46 kV to 30 kV, exhibiting low fire resistance.

Thirst in critical patients and its associated factors.

Objectives: to assess prevalence, intensity, discomfort, defining characteristics of thirst and signs of oral mucosa hydration in Intensive Care Unit patients.

Methods: quantitative and analytical study, carried out in a tertiary hospital in six of the seven Intensive Care Units, with a sample of 60 patients. Variables related to thirst were analyzed according to their nature.

Mobile application for first aid to children: a technological innovation in schools.

Objectives: to develop a mobile application for first aid to children, designed for use by basic education professionals.

Methods: we carried out this applied research in three phases: 1-integrative review, 2- identification of learning needs through a cross-sectional study with 53 school professionals, and 3- app development.

Results: the Child and Care (Criança e Cuidado) app includes three main sections (Important contacts, Learn first aid, and Record the accident).