Publications by authors named "M C Bue"
This review aimed to summarize the current literature on antibiotic distribution in orthopedically relevant tissues and settings where dynamic sampling methods have been used. PubMed and Embase databases were systematically searched. English-published studies between 2004 and 2024 involving systemic antibiotic administration in orthopedically relevant tissues and settings based on dynamic measurements were included.
View Article and Find Full Text PDFTherapies based on mesenchymal stromal cells (MSCs) have become one of the most significant advancements in veterinary regenerative medicine. The isolation of MSCs is usually performed by enzymatic digestion and requires variable times for cell expansion. In addition, these procedures need to be performed in specialized laboratory facilities.
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- Animal models play a crucial role in researching orthopedic infections, specifically osteomyelitis, but current models are limited in replicating real-life treatment scenarios.
- Large animal models, particularly sheep and pigs, are necessary for comprehensive studies, with a focus on a specific porcine model that allows for effective testing of surgical interventions for implant-related infections.
- The review discusses the advantages and disadvantages of the porcine model in relation to existing large animal models, providing insights for future research in orthopedic infections.
Article Synopsis
- - The study aimed to evaluate the wrist stabilizing effects and mechanical properties of four different materials used for wrist splints, including plaster of Paris (PoP), Woodcast, X-lite, and a 3D-printed polypropylene material.
- - Using cadaveric arm specimens, researchers tested how well each splint material resisted wrist flexion and extension under a controlled load, and they also conducted a bending test on samples of each material.
- - Results showed that PoP provided superior wrist stability and stiffness compared to the other materials, suggesting it may be the best option for wrist immobilization despite new alternatives like 3D printing.
The therapeutic challenges of orthopedic device-related infections and emerging antimicrobial resistance have attracted attention to drug delivery technologies. This study evaluates the preclinical efficacy of local single- and dual-antibiotic therapy against implant-associated osteomyelitis (IAO) using a drug-eluting depot technology, CarboCell, that provides sustained release of high-dose antibiotics and allows for strategic placement in relation to infectious lesions. Clindamycin and gentamicin were formulated in CarboCell compositions.
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