Publications by authors named "M C Brindisi"
Article Synopsis
- The study aimed to investigate how common mental health issues and multiple disorders (multimorbidity) are among a large sample of French adults, focusing on women and men.
- Data analysis of over 33,000 participants revealed that 40.6% reported at least one mental disorder, with a higher prevalence of disorders among women compared to men.
- The research highlights specific patterns, such as overweight and smoking habits among men with multiple disorders, suggesting implications for public health strategies and further studies on mental health.
Triple negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by the lack in the expression of estrogen and progesterone receptors, and human epidermal growth factor receptors 2. TNBC stands out among other breast cancers subtypes for its high aggressiveness and invasiveness, and for the limited therapeutic options available, which justify the poor survival rates registered for this breast cancer subtype. Compelling new evidence pointed out the role of epigenetic modifications in cancer, prompting tumor cell uncontrolled proliferation, epithelial-to-mesenchymal transition, and metastatic events.
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- The study aimed to investigate how people with obesity (OB) process taste information compared to normal-weight individuals (NW) by examining gustatory evoked potentials (GEP) in response to a sucrose solution before and after eating a standard lunch.
- Participants included 28 individuals with obesity and 22 normal-weight individuals, who underwent tests in two sessions: one after fasting and one after consuming a low-sugar lunch.
- Results showed that OB subjects had longer GEP latencies, indicating slower activation of the taste cortex, and their GEP responses did not change after eating, unlike NW participants, with correlations found between GEP latencies and certain hormone levels.
Key epitranscriptomic players have been increasingly characterized for their structural features and their involvement in several diseases. Accordingly, the design and synthesis of novel epitranscriptomic modulators have started opening a glimmer for drug discovery. m6A is a reversible modification occurring on a specific site and is catalyzed by three sets of proteins responsible for opposite functions.
View Article and Find Full Text PDFA First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Strain, Computational Investigation and in Vivo Validation in a Fungal Infection Model.
J Med Chem
August 2024
The widespread and irrational use of azole antifungal agents has led to an increase of azole-resistant strains with an urgent need for combination drug therapy, enhancing the treatment efficacy. Here, we report the discovery of a first-in-class pyrazole-isoxazole, namely, , that showed remarkable growth inhibition against the . ATCC 10231 strain in combination with voriconazole, acting as a downregulator of ERG 11 () gene expression with a significant reduction of the yeast-to-hypha morphological transition.
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