A paper-based HPV E7 oncoprotein assay for cervical precancer detection at the point of care.

Cervical cancer, while preventable through screening and treatment of cervical precancer, remains a global challenge with a disproportionately high burden of disease in resource-limited settings, especially in low- and middle-income countries (LMICs). Lack of affordable, easy-to-use screening and diagnostic tests contributes to this disparity. Most commercially available tests are not appropriate for use in LMICs due to resource constraints.

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk.

Osteoarthritis (OA) poses a significant healthcare burden with limited treatment options. While genome-wide association studies (GWASs) have identified over 100 OA-associated loci, translating these findings into therapeutic targets remains challenging. To address this gap, we mapped gene expression, chromatin accessibility, and 3D chromatin structure in primary human articular chondrocytes in both resting and OA-mimicking conditions.

Prognostic value of radiologic and pathological response in colorectal cancer liver metastases upon systemic induction treatment: subgroup analysis of the CAIRO5 trial.

Background: RECIST may not be optimal for assessing treatment response with current systemic regimens. We evaluated RECIST, morphologic, and pathologically documented response (pathological response) in patients with initially unresectable colorectal cancer liver-only metastases (CRLM).

Patients And Methods: Four hundred and eighty-nine patients from the phase III CAIRO5 trial were included who were treated with FOLFOX/FOLFIRI/FOLFOXIRI and bevacizumab or panitumumab.

Strong-ties and weak-ties rationalities: toward a mental model of the consequences of kinship intensity.

There is growing evidence of the connection between variations in kinship intensity and cross-cultural differences in psychological traits. Contributing to this literature on kinship intensity, we put forward a mental model to explain the enduring connection between ancestral niche and psychological traits. Our model posits that two primary orientations or dispositions-strong-ties and weak-ties rationalities-have co-evolved with our ancestral niches to perpetuate-by internalizing and reproducing-the social structure (such as preferences for certain attitudes, values, and beliefs) of the ancestral niche.