Publications by authors named "M C Andrieu"
In Streptococcus pyogenes, the type II fatty acid (FA) synthesis pathway FASII is feedback-controlled by the FabT repressor bound to an acyl-Acyl carrier protein. Although FabT defects confer reduced virulence in animal models, spontaneous fabT mutants arise in vivo. We resolved this paradox by characterizing the conditions and mechanisms requiring FabT activity, and those promoting fabT mutant emergence.
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- Insertional Achilles tendinopathy (IAT) is primarily caused by mechanical overload, with running and obesity as key risk factors; while surgery may be necessary, the best surgical approach remains debated.
- The study hypothesizes that endoscopic surgery will lead to quicker functional recovery and faster return to sports compared to traditional open surgery methods.
- Results show that patients who underwent endoscopic surgery returned to sports significantly faster than those who had open surgery, but long-term outcomes appear similar for both methods, suggesting endoscopic calcaneoplasty is effective yet requiring further research for long-term validation.
Introduction: People living with HIV (PLWH) now benefit from combined antiviral treatments that durably control viral replication. These antiretroviral treatments decrease mortality and improve quality of life in PLWH, but do not completely control the excessive non-specific activation of the immune system in PLWH. This chronic immune activation is a key element of HIV immunopathology that contributes to the pathophysiology of inflammatory comorbid conditions, such as cardiovascular disorders, cancer and autoimmune diseases.
View Article and Find Full Text PDFHippocampal and neocortical BRAF mutant non-expansive lesions in focal epilepsies.
Neuropathol Appl Neurobiol
October 2023
Objective: Mesial Temporal Lobe Epilepsy-associated Hippocampal Sclerosis (MTLE-HS) is a syndrome associated with various aetiologies. We previously identified CD34-positive extravascular stellate cells (CD34+ cells) possibly related to BRAF oncogenic variant in a subset of MTLE-HS. We aimed to identify the BRAF oncogenic variants and characterise the CD34+ cells.
View Article and Find Full Text PDFFive-year clinical follow-up of arthroscopically treated chronic ankle instability.
Orthop Traumatol Surg Res
December 2023
Introduction: Arthroscopic treatment of lateral ankle instability is a recent innovation. In 2014, a prospective study was initiated by the French Society of Arthroscopy demonstrating the feasibility, morbidity and short-term results of arthroscopic treatment of ankle instability.
Hypothesis: The functional results of arthroscopic treatment of chronic ankle instability found after one year were maintained in the medium term.