PAV-05 Naphthoquinone Potently Inhibit Zika Virus Replication in Infected Cells.

Background: Zika (ZIKV) is a virus transmitted by mosquitoes that can cause Guillain- Barré syndrome and congenital malformations like microcephaly. Given its explosive resurgence and the resulting epidemics in 2016, the search for effective antiviral drugs has become absolutely necessary.

Methods: In this study, we examined the potential of naphthoquinone derivatives that have a sulfonamide or sulfonate group to inhibit ZIKV replication in primary cultured neurons and in Vero cells.

Transplacental sirolimus for reversal of fetal heart failure due to fetal cardiac rhabdomyoma: fetal and maternal considerations.

Background: Rhabdomyoma is the most common cardiac tumor in fetal life. It has frequent association with tuberous sclerosis complex and may lead to heart failure, a potentially fatal condition. The use of transplacental sirolimus, a mTOR inhibitor, has emerged as a novel treatment in symptomatic fetal rhabdomyomas, there are, though, only few cases described.

Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers.

Erythropoietin-producing hepatocellular (Eph) receptors comprise the largest group of surface receptors and are responsible for cellular signals. Eph/ephrin signaling has been identified to play a role in key cancer development and progression processes, especially in the upper gastrointestinal tract. The Eph/ephrin system has been described as a tumor suppressor in duodenal cancer, while in esophageal, gastric, hepatic, and pancreatic cancer, the system has been related to tumor progression.

Voices of the Past: A Case Report on the Interaction Between Childhood Trauma, Social Phobia, and Psychotic Symptoms in a Transgender Male.

This case report explores the interplay between childhood trauma, social phobia, psychotic symptoms, and minority stress in a 27-year-old transgender male. L presented with psychotic symptoms, including auditory verbal hallucinations and self-referential phenomena, which were accompanied by a history of childhood sexual and emotional abuse, as well as social phobia. These challenges were further compounded by experiences of stigma, rejection, and stress related to his gender identity.

Oral lesions and disorders and their prevalence arising from the use of illicit drugs in a prison population.

Background: The dependence on the illicit drugs has been proven to be harmful to the oral cavity and may lead to a series of abnormal manifestations. The main objective of this study was to observe the effects caused by the consumption of illicit drugs in the oral cavity, in a prison population in the North of Portugal.

Methods: A cross-sectional observational study was conducted involving 91 male inmates aged 25-75 years (mean age 41.