Topical siRNA therapy of diabetic-like wound healing.

Non-healing wounds are a serious complication in diabetic patients. One of the detrimental factors contributing to limited wound healing is the accumulation of metalloproteinase-9 (MMP-9) in the wound. Selective inhibition of MMP-9 is one of the established therapeutic targets for diabetic wound healing.

Optimization of Electrospun TORLON 4000 Polyamide-Imide (PAI) Nanofibers: Bridging the Gap to Industrial-Scale Production.

Polyamide-imide (PAI) is an exceptional polymer known for its outstanding mechanical, chemical, and thermal resistance. This makes it an ideal choice for applications that require excellent durability, such as those in the aerospace sector, bearings, gears, and the oil and gas industry. The current study explores the optimization of TORLON 4000 T HV polyamide-imide nanofibers utilizing needleless electrospinning devices, ranging from laboratory-scale to industrial-scale production, for the first time.

The Gradual Release of Alendronate for the Treatment of Critical Bone Defects in Osteoporotic and Control Rats.

Purpose: Osteoporosis is a severe health problem with social and economic impacts on society. The standard treatment consists of the systemic administration of drugs such as bisphosphonates, with alendronate (ALN) being one of the most common. Nevertheless, complications of systemic administration occur with this drug.

Optimal microstructure and mechanical properties of open-cell porous titanium structures produced by selective laser melting.

Three-dimensional printing technology enables the production of open cell porous structures. This has advantages but not only in terms of weight reduction. In implant structures, the process of osseointegration is improved, mechanical integration is better, the open cell porous structures resemble a trabecular structure that mimics bone tissue.