Publications by authors named "M Burleigh"

Interest in the role of dietary nitrate in human health and disease has grown exponentially in recent years. However, consensus is yet to be reached as to whether consuming nitrate from various food sources is beneficial or harmful to health. Global authorities continue to recommend an acceptable daily intake (ADI) of nitrate of 3.

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Background: The oral microbiome-dependent nitrate (NO )-nitrite (NO )-nitric oxide (NO) pathway may help regulate blood pressure. NO -producing bacteria in subgingival plaque are reduced in relative abundance in patients with untreated periodontitis compared with periodontally healthy patients. In periodontitis patients, the NO -producing bacteria increase several months after periodontal treatment.

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Background: Nitrate (NO) has been suggested as a prebiotic for oral health. Evidence indicates dietary nitrate and nitrate supplements can increase the proportion of bacterial genera associated with positive oral health whilst reducing bacteria implicated in oral disease(s). In contrast, chlorhexidine-containing mouthwashes, which are commonly used to treat oral infections, promote dysbiosis of the natural microflora and may induce antimicrobial resistance.

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Article Synopsis
  • The study assesses how periodontitis affects the oral microbiota's ability to reduce nitrate to nitrite, which is crucial for oral health and nitric oxide production.
  • Analysis showed lower levels of nitrate-reducing bacteria in patients with periodontitis compared to healthy individuals, suggesting a link between these bacteria and periodontal health.
  • After periodontal treatment, patients exhibited improved nitrate-reducing capacity and an increase in beneficial bacteria, highlighting the potential impact of oral health on systemic conditions influenced by nitric oxide.
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