Publications by authors named "M Burattini"
Immun Ageing
October 2024
Article Synopsis
- Systemic inflammation raises the risk of mortality in hospitalized older patients, especially in the context of age-related diseases and infections like COVID-19.
- Inflammatory biomarkers such as the C-reactive protein to albumin ratio (CAR) and various prognostic scores (GPS, mGPS, hs-mGPS) effectively predict short-term mortality but are often underused for this purpose.
- The study involving 3,206 geriatric patients found that higher CAR and higher GPS scores significantly correlated with increased mortality risk, especially in men, indicating that these inflammatory markers can help assess in-hospital mortality risk in older adults.
Article Synopsis
- The study focuses on how electrical and mechanical functions of the heart can be affected by diseases, using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as a model for research.
- It explores innovative methods to evaluate the electrical and mechanical properties of hiPSC-CMs associated with inherited heart conditions, specifically Brugada syndrome and dilated cardiomyopathy, by organizing them into a bilayer configuration.
- The research employs advanced techniques such as high-density microelectrode arrays and various microscopy methods to measure cardiac functions and responses to stimulation, providing a comprehensive approach to understanding disease mechanisms and potential drug responses.
