Publications by authors named "M Burai"
Background/objectives: Malignant pancreatobiliary strictures are in many cases clinically indistinguishable and present a major problem to endoscopy specialists. Intraductal sampling procedures such as brush cytology are commonly used for diagnosis with a sensitivity that is low for a diagnostic test used in daily clinical practice. MicroRNA (miR) alterations detected in many cancers are disease-specific, which can be utilized in clinical applications.
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- Colonoscopy remains the gold standard for diagnosing colorectal cancers but has low patient compliance due to discomfort and risks associated with the procedure.
- A study compared the sensitivity and specificity of a double immunochemical FECA test for faecal haemoglobin and albumin against colonoscopy, finding the test had a sensitivity of 52.7% and specificity of 92.3% for significant neoplastic lesions.
- While the FECA test showed better sensitivity than other non-invasive tests, it still doesn't match colonoscopy, suggesting that the latter may still be necessary as a primary screening method in some cases.
Two hundred and five preoperative intraductal samplings (brushing and biopsy) were evaluated from 113 patients with biliary or Wirsung duct strictures. One hundred and three strictures could be specified by histology of the operative specimens, autopsy, or by the patients' clinical course. Preoperative diagnostic efficacy depended on the tumor location (it was the best for ampullary and para-papillary tumors), but the average quantitative indices for sensitivity, absolute sensitivity, specificity, positive and negative predictive values, diagnostic accuracy of cytology were 53%, 20%, 100%, 100%, 25%, 59%, respectively.
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