Publications by authors named "M Bulthuis"
Article Synopsis
- Oral focus screening before hematopoietic cell transplantation (HCT) is critical, yet the impact of chronic dental issues on post-transplant health is not well understood.
- A study of 500 patients highlighted that nearly half had untreated chronic dental problems, and those with three or more issues stayed in the hospital five days longer on average.
- The research found that while having multiple dental foci increased hospital length of stay, it did not significantly affect early mortality rates post-HCT.
Article Synopsis
- The study aimed to evaluate the salivary flow rates, perceived oral dryness, and dental caries in patients five years after undergoing hematopoietic cell transplantation (HCT).
- A total of 39 survivors participated, with results showing a mean unstimulated saliva flow rate of 0.36 mL/min and a stimulated flow rate of 1.02 mL/min, while 73% reported experiencing some level of oral dryness.
- The findings indicated that there was a slight increase in dental treatments needed post-HCT, with survivors undergoing an average of three treatments over five years following the transplant, although these changes were non-significant when compared to pre-transplant metrics.
Background: Post-COVID-19 syndrome (PCS) remains a major health issue worldwide, while its pathophysiology is still poorly understood. Systemic oxidative stress (OS) may be involved in PCS, which is reflected by lower circulating free thiols (R-SH, sulfhydryl groups), as they are receptive to rapid oxidation by reactive species. This study aimed to investigate the longitudinal dynamics of serum R-SH after SARS-CoV-2 infection and its association with the development of PCS in individuals with mild COVID-19.
View Article and Find Full Text PDFAims: Calciprotein particles (CPPs) are circulating calcium and phosphate nanoparticles associated with the development of vascular calcification (VC) in chronic kidney disease (CKD). Although recent studies have been focusing on associations of CPPs with the presence of VC in CKD, insights in the underlying processes and mechanisms by which CPPs might aggravate VC and vascular dysfunction in vivo are currently lacking. Here, we assessed the overall burden of abdominal VC in healthy kidney donors and CKD patients and subsequently performed transcriptome profiling in the vascular tissue obtained from these subjects, linking outcome to CPP counts and calcification propensity.
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