Possible link between familial susceptibility to cancer and the level of oxidative stress in thyroid cancer patients.

Background: Hereditary cancer is estimated to account for up to 10% of the worldwide cancer burden; 5% of all thyroid cancers are thought to be genetic. Inheritance of a deleterious mutation in genes associated with a high lifetime risk of developing cancer. Cancer-predisposing genes can promote the initiation and progression of thyroid cancer by enhancing the activation of major signaling pathways through oxidative stress mechanisms.

ROLE OF Β-ADRENOCEPTORS IN REGULATION OF ERYTHROCYTES' RHEOLOGICAL FUNCTIONS (REVIEW).

In this review, we discuss the role of adrenoceptors in the regulation of the rheological functions of erythrocytes. β-adrenoceptors play an important role in the regulation of erythrocytes functions and metabolism. They participate in the modification of transport membrane proteins (Na+/K+-ATPase, Ca+2-ATPase, Na+/K+/2Cl-cotransporter, Na+/H+-antiporter, CAT-1, Ca2+-dependent K+ channels (Gard channels), the activity of adenylate cyclase and cAMP, AMP-dependent activation of the L-arginine/NOS system and erythrocyte NOS) and by this way modulate the cells volume, rheological properties (deformability, aggregability), intensity of NO synthesis and ATP reliase.

RISK-FACTORS OF CORONARY ARTERY DISEASE (REVIEW).

The treatment of coronary arteries disease (CAD) and the prevention of their complications, intervention on the coronary arteries is usually recommended. In this review, with the aim of improving the treatment outcomes of patients with CAD, requiring percutaneous coronary intervention and/or coronary artery bypass grafting,risk factors of developing coronary syndrome are discussed. Understanding the causes of the disturbance of coronary artery conduction will provide a new perspective for improving patient treatment outcomes.

[THE STRUCTURE AND RISK OF CHRONIC MORBIDITY IN SOME VILLAGES OF THE UPPER IMERETI REGION OF WEST GEORGIA AND THEIR MOLECULAR AND CYTOGENETIC MARKERS].

The purpose of our study was to identify the nature of the cause-effect relationship between the risks of developing of Chronic Obstructive Pulmonary Disease (COPD) and Cardio-vascular Disease (CVD) in patients residing in the villages of Chiatura district, characterized by varying degrees of environmental stress. The residents (n=400) of the Chiatura district living in the villages, Khreiti, Perevisa and Rgani were examined. The villages are characterized by different degrees of ecological tension (the villages differ both in their remoteness from sources of environmental pollution - manganese mining quarries and the scale of its extraction, which allows them to rank according to the degree of environmental tension: Khreiti - low, Perevis - medium, Rgani - high).

[SCREENING LEVEL ENVIRONMENTAL HEALTH RISK ASSESSMENT BY HEALTH DATA IN SOME SMALL AREAS OF UPPER IMERETI (CHIATURA DISTRICT)].

The article presents the results of a comparative analysis of health data in villages Rgani, Perevisa and Khreiti population (Chiatura municipality), Which were obtained by the initiative group of the ak. N. Kipshidze Republican Hospital within the framework of the universal healthcare program of population insurance.