Magnesium ions and opioid agonists in vincristine-induced neuropathy.

Neuropathic pain is difficult to treat. Classic analgesics (i.e.

Modification of fentanyl analgesia by antidepressants.

Clinical practice often requires simultaneous administration of antidepressants with opioids (oncology, rheumatology). Coadministration may either attenuate or potentiate opioid analgesia. The purpose of this paper was to verify how the analgesic action of fentanyl (0.

Bradykinin receptor antagonists and cyclooxygenase inhibitors in vincristine- and streptozotocin-induced hyperalgesia.

Pain that accompanies neuropathy is difficult to treat. Analgesics administered as monotherapies possess low activities in relieving this kind of pain. The effect of the simultaneous administration of indomethacin (a preferential inhibitor of cyclooxygenase-1; COX-1) or celecoxib (a relatively selective inhibitor of cyclooxygenase-2; COX-2), with selective antagonists of bradykinin(2) (B(2)) bradykinin(1) (B(1)) receptors (HOE 140 or des-Arg(10)-HOE 140) on the alleviation of diabetic and toxic neuropathic pain was investigated.

Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model.

Purpose: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.

Effect of selol on the opioids activity in streptozotocin induced hyperalgesia.

We examined the effect of the opioid receptor agonists and the effect of an antioxidant selol, which is an organoselenium compound on antinociceptive action of opioid agonists in diabetic neuropathic pain model. Streptozotocin (STZ) induced hyperglycemia accompanied by a prolonged decrease in nociceptive threshold is considered a useful model of experimental hyperalgesia. The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal Randall-Selitto test.