Publications by authors named "M Buelent Akinci"
Background: Cerebrospinal fluid (CSF) biomarkers of synaptic dysfunction, neuroinflammation, and glial response, complementing Alzheimer's disease (AD) core biomarkers, have improved the pathophysiological characterization of the disease. Here, we tested the hypothesis that the co-expression of multiple CSF biomarkers will help the identification of AD-like phenotypes when biomarker positivity thresholds are not met yet.
Methods: Two hundred and seventy cognitively unimpaired adults with family history (FH) of sporadic AD (mean age = 60.
Deep learning in distinguishing pulmonary nodules as benign and malignant.
Turk Gogus Kalp Damar Cerrahisi Derg
July 2024
Article Synopsis
- - The study aimed to improve early lung cancer diagnosis by developing convolutional neural network models to accurately differentiate between benign and malignant lung nodules using diagnostic imaging data from 2015 to 2020.
- - Patients were categorized into three groups—benign, malignant, and control—while deep neural networks were trained on 80% of their data and tested on the remaining 20%, showing an accuracy of up to 80% with AlexNET and 93.5% when using a support vector machine classifier with the VGG19 model.
- - The findings indicate that utilizing deep learning and feature extraction effectively enhances the ability to identify lung nodules, supporting early diagnosis and potentially improving radiology practices.
Article Synopsis
- The study aimed to assess how aware community-dwelling women aged 60 and over are of their pelvic floor muscles and related exercises, and how this awareness relates to urinary incontinence.
- It included a survey of 500 women, revealing that both knowledge and awareness of pelvic floor muscles and exercises were generally low, especially among those with urinary incontinence.
- The findings suggest that educational programs are needed to improve understanding and proper practice of pelvic floor muscle exercises in this age group.
Glial reactivity may contribute to sex/gender differences in Alzheimer's disease (AD) pathophysiology. Here, we investigated the differential effect of cerebrospinal fluid (CSF) glial markers on AD pathology and neurodegeneration by sex/gender among cognitively unimpaired older adults at increased risk of developing AD. We included 397 participants from the ALFA+ cohort with CSF Aβ, p-tau, sTREM2, YKL40, and GFAP, magnetic resonance imaging-based hippocampal volume (n = 299), and amyloid burden (centiloids) measured with [F] flutemetamol positron emission tomography (n = 341).
View Article and Find Full Text PDFThis study examines the impact of the combination of sitagliptin and L-theanine on the testis tissue of rats with experimental diabetes. Diabetes mellitus, a chronic metabolic illness, significantly reduces quality of life and can cause male infertility by decreasing sperm count, motility, and testosterone levels. Rats were allocated to five separate groups: control, diabetes, L-theanine, sitagliptin, and combination therapy.
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